In breast cancer, tanshinone I downregulates hypoxia-inducible factor 1alpha (HIF-1α) and VEGF in breast cancer MDA-MB-231 cells, and tanshinone IIA inhibits the angiogenesis and growth of human breast cancer xenografts in nude mice through suppression of HIF-1α and VEGF (Nizamutdinova et al., 2008a; Liao et al., 2020). The gene discussed is HIF1A; the disease is breast carcinoma.