, Arctigenin (from Arctium lappa L.), and cyperenoic acid (from Croton crassifolius Geiseler) can inhibit the tube formation of HUVECs in vitro and exhibit antiangiogenesis of breast cancer in vivo by inhibiting the expression of angiogenic growth factors and HIF-1α/VEGF signal pathway (Wang et al., 2017; Zhang et al., 2017; Li C. et al., 2018; Zhao et al., 2018). The gene discussed is HIF1A; the disease is breast carcinoma.