TP53 and cervical cancer: It is reported in other studies that tanshinone IIA inhibits the proliferation of human cervical cancer CaSki, SiHa, HeLa, and C33a cells in vitro, leading to a 66% reduction in the volume of cervical cancer xenograft in vivo by inducing S phase cell cycle arrest and p53-mediated apoptosis (Munagala et al., 2015).