Positron emission tomography (PET) imaging of tau in tauopathy mouse models using various tau-targeted radioligands has been established (Maruyama et al., 2013; Brendel et al., 2016; Ono et al., 2017; Ishikawa et al., 2018; Ni et al., 2018; Tagai et al., 2020; Chaney et al., 2021; Cao et al., 2022). This evidence concerns the gene MAPT and tauopathy.