MAPT and tauopathy: Animal models recapitulating tauopathy have facilitated the understanding of disease mechanisms and the development of treatment strategies (Albert et al., 2019; Roberts et al., 2020; Ayalon et al., 2021), including transgenic mouse lines P301S (PS19), EC-tau, P301L (JNPL3, rTg4510, pR5), rTg21221 (Lewis et al., 2000; Ramsden et al., 2005; Santacruz et al., 2005; Yoshiyama et al., 2007; Hoover et al., 2010; de Calignon et al., 2012) and rat models (Filipcik et al., 2012).