MAPT and tauopathy: Hyperneuronal activity has been shown to enhance tau secretion and exacerbate tau pathology in several tauopathy mouse models, including rTg4510, EC-Tau (Wu et al., 2016), Thy-Tau22 (Gomez-Murcia et al., 2020), and the TAU58/2 lines (Przybyla et al., 2020).