Other recent studies have revealed the significant roles of SorCS2 in brain derived neurotrophic factor (BDNF)-dependent plasticity and for social memory formation by N-methyl-D-aspartic (NMDA) receptor trafficking in hippocampal neurons (Glerup et al., 2016; Yang et al., 2021); in parallel, working memory deficits (Martinussen et al., 2005; Sowerby et al., 2011) and the involvement of BDNF or NMDA receptor signaling in ADHD have also been suggested (Bergman et al., 2011; Chang et al., 2014). The gene discussed is BDNF; the disease is attention deficit-hyperactivity disorder.