In tumor tissues, there exists a significant association between the polymorphisms of TIM-3 and PD-1 (programmed cell death 1) and the expression level of TIM-3 and PD-1, such that by administrating PD-1 and TIM-3 synergistic promotion of tumor growth would be observed (Topalian et al., 2012[61]). This evidence concerns the gene HAVCR2 and neoplasm.