LAG3 and neoplasm: The function of LAG-3 includes the control of excessive activation after persistent exposure to antigens in order to prevent autoimmunity (Koirala et al., 2016[27]; Wang et al., 2016[67]); nonetheless, it is capable of making a contribution to the conditions under which T cells dysfunction in the tumor microenvironment (TME) (Liu et al., 2016[32]).