There are already clear examples of population-enriched clinically important variants only discovered in underrepresented populations; a few of these include associations between APOL1 and chronic kidney disease11, variants in G6PD that contribute to missed diabetes diagnosis12, and loss-of-function variants in PCSK9 that lower LDL cholesterol (the discovery that led to PCSK9 inhibitor drugs)13, all of which were identified in populations with African ancestry. The gene discussed is PCSK9; the disease is diabetes mellitus.