NR4A1 and neoplasm: When looking into patients with early relapse during the first 5 years following diagnosis, baseline CTC positivity was independently prognostic for shorter DFS at the multivariable analysis when adjusting for age, tumour size, nodal status, grade and hormone receptor status (HRadj = 1.76, 95% CI 1.33–2.32, p < 0.001; Fig. 2).