Distinct from janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2), the abundance of IFNAR1, IFNAR2, signal transducer and activator of transcription 1 (STAT1), signal transducer and activator of transcription 1 (STAT2), interferon regulatory factor 9 (IRF9), and MX dynamin-like GTPase 1 (MX1) are predictors of good prognosis of melanoma (Fig. 1D–K). Here, TYK2 is linked to melanoma.