IFNAR2 and nevus: We further compared the expressions of IFNAR1 and IFNAR2 in normal skins, nevus tissues, and melanoma tissues using a published dataset (GSE3189) and found that the expressions of IFNAR1 and IFNAR2 are significantly higher in melanoma as compared to normal skin and nevus tissues (Fig. 1C and Supplementary Fig. S1C) [25].