MUC5AC and metastatic neoplasm: In addition, only 6 of 190 patients (3%) in Group A developed metastatic disease, compared to 37 of 122 (30%) in Group B and 59 of 107 (55%) in Group C. The 6 cases in Group A with metastatic disease all had Gleason pattern 4 architecture other than “small” cribriform glands, including 5 with anastomosing cords of carcinoma cells with variable lumen formation (Canary pattern Cz6) and one case with architecturally complex epithelium floating in confluent pools of mucin (Canary pattern Ew6).