We further characterized two A3B interacting proteins: SAFB, which is a nuclear matrix protein known to form molecular assemblies28, and which interacted with A3B in an RNA-independent manner (shown in Fig. 2), and ILF2, which interacted with A3B in an RNA-dependent manner and which is the only protein shown to contribute to multiple myeloma pathogenesis29 among the interacting proteins listed so far. The gene discussed is APOBEC3B; the disease is plasma cell myeloma.