However, the insignificant change in KRT82 levels in AAP nonlesional compared to lesional biopsy sites (p = 0.068) suggested that decreased expression observed in patients was not a result of the absence of HFs, but rather a predisposed reduction in functional KRT82 expression that strongly correlated with active disease sites and disease severity (Fig. 7b). Here, KRT82 is linked to Hand-foot syndrome.