For example: the gene encoding SAP97, DLG1, was recently identified as a potential hub of schizophrenia-related synaptic dysfunction13; missense mutations in SAP97 have been identified in individuals with schizophrenia12,14; and microdeletion mutations in humans resulting in the loss of a DLG1 allele give rise to a 40-fold increase in the risk of developing schizophrenia8,9. Here, DLG1 is linked to schizophrenia.