ATM and neoplasm: In an animal model of U251R xenograft model as we reported before [10], the immunohistochemistry (IHC) and western blot results of tumor tissue indicated that ATM expression was decreased with fasudil treatment, and γH2AX level was increased with fasudil and TMZ treatment (Supplementary Fig. S7, WB blots were also given in Original Data of WB blots).