ROCK2 and central nervous system cancer: As showed in Fig. 3 and Supplementary Fig. S4, in MGMTlow TMZ-R glioma cells, the γH2AX signal persisted in ROCK2-KD cells or fasudil (ROCK2 inhibitor, 10 μM) treatment, whereas the subsequent recruitment of the HR factors was substantially attenuated, suggesting an impaired repair in MGMTlow TMZ-R cells.