Furthermore, double immunostainings revealed that the percentages of F4/80+ cells positive for the anti-inflammatory M2 macrophagic markers pSTAT3 [33–35] peroxisome-activated proliferator receptor-γ (PPARγ) [33, 36, 37] and c-MYC [33, 38, 39] were globally enhanced in both bronchial/bronchiolar and alveolar parenchyma of mutant mice as well as in adenomas compared to control (Fig. 7A–F), thus indicating a BRAFV600E-mediated overall increase in pro-tumoral macrophages in lungs. Here, PPARG is linked to adenoma.