HIF1A and adenoma: Conversely, F4/80+ cells positive for the pro-inflammatory M1 macrophagic marker hypoxia inducible factor-1α (HIF1α) [35, 40–42] were significantly increased only in adenomas, but not in either alveolar or bronchial/bronchiolar parenchyma of mutant mice compared to controls (Supplementary Fig. 11A, B), thus giving further confirmation on the ability of BRAFV600E to orchestrate the immediate recruitment of specific leukocytes in different pulmonary epithelia.