Albeit in BRAFV600E mice both non-tumor alveolar parenchyma and adenomas showed increased p21CIP1 levels compared to controls (Fig. 2H, Fig. 3G, Supplementary Fig. 4), neither smaller nor larger adenomas show significant changes in p21CIP1 levels compared to non-tumor BRAFV600E alveolar zones (Supplementary Fig. 6A). This evidence concerns the gene CDKN1A and neoplasm.