To determine if SWELL1-mediated currents are altered in T2D we measured ICl,SWELL in pancreatic β-cells freshly isolated from T2D mice raised on HFD for 5–7 months (Fig. 1a, c) and from individuals with T2D (Fig. 1b, d and Supplementary Table S1) compared to non-T2D controls. The gene discussed is LRRC8A; the disease is type 2 diabetes mellitus.