Similarly, we found previously that SWELL1 ablation markedly reduces insulin-pAKT2-pGSK3β signaling24,26,27 and cellular glycogen content24, and accordingly asked whether the SN-401-mediated increase in SWELL1 signaling would increase glucose incorporation into tissue glycogen in the setting of T2D. This evidence concerns the gene LRRC8A and type 2 diabetes mellitus.