In vivo, SN-401 augmented SWELL1 expression twofold in adipose tissue of HFD-fed T2D (Fig. 3a), threefold in adipose tissue of KKAy T2D (Fig. 3b) mice, and was associated with improved fasting blood glucose (FG), glucose tolerance (GTT), and insulin tolerance (ITT) in both T2D models (Fig. 3c–f). Here, LRRC8A is linked to type 2 diabetes mellitus.