Similarly, SWELL1-mediated ICl,SWELL measured in isolated human adipocytes from a diabetic individual with obesity (BMI = 52.3, HgbA1c = 6.9%; Fasting glucose = 148–151 mg/dl) show a trend toward being reduced 48% compared to non-diabetic individuals with obesity that we reported previously24, and not different from ICl,SWELL in adipocytes from lean individuals (Fig. 1h and Supplementary Table S3). This evidence concerns the gene LRRC8A and obesity due to melanocortin 4 receptor deficiency.