Similarly, SWELL1 protein is 50% lower in adipose tissue from individuals with hyperglycemic T2D and obesity (HgbA1c > 6.0%) compared to adipose tissue from normoglycemic individuals (HgbA1c < 6.0% Fig. 1k and Supplementary Table S4). The gene discussed is LRRC8A; the disease is obesity due to melanocortin 4 receptor deficiency.