LRRC8A and type 2 diabetes mellitus: Glucolipotoxicity and ensuing ER stress associated with T2D states60–62 provide an unfavorable environment for SWELL1-LRRC8 complex assembly, contributing to SWELL1 degradation and reductions in SWELL1 protein and SWELL1-mediated ICl,SWELL observed in T2D in some tissues.