Similarly, SWELL1-mediated ICl,SWELL measured in isolated human adipocytes from a diabetic individual with obesity (BMI = 52.3, HgbA1c = 6.9%; Fasting glucose = 148–151 mg/dl) show a trend toward being reduced 48% compared to non-diabetic individuals with obesity that we reported previously24, and not different from ICl,SWELL in adipocytes from lean individuals (Fig. 1h and Supplementary Table S3). The gene discussed is LRRC8A; the disease is Obesity.