Consistent with improved glucose metabolism in peripheral tissues, we observe a trend toward SN-401 mediated SWELL1 induction in skeletal muscle (Supplementary Fig. 5a, b) in HFD-T2D mice (18 weeks HFD), associated with increases in downstream pAKT2, pAS160, and pGSK3β (Ser9) signaling (Supplementary Fig. 5a, b). This evidence concerns the gene LRRC8A and type 2 diabetes mellitus.