Consistent with reductions observed in murine and human adipocyte ICl,SWELL, SWELL1 protein is also reduced (38%) in adipose tissue of T2D KKAy mice as compared to parental control KKAa mice (Fig. 1i), and 66% in obese T2D mice raised on HFD for 33 weeks (40 weeks old) compared to lean mice (Fig. 1j). Here, LRRC8A is linked to type 2 diabetes mellitus.