INS and Insulin resistance: Similarly, in a separate experiment, SN-406 significantly improved glucose tolerance in HFD-T2D mice, compared to Inactive 1 (Fig. 10c), and this is associated with a trend toward improved insulin sensitivity based on the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)57 (Fig. 10d), and significantly augmented insulin secretion in perifusion GSIS (Fig. 10e).