LRRC8A and type 2 diabetes mellitus: Similar to these prior findings, hepatic SWELL1 protein is induced ninefold in mice raised on HFD for 33 weeks compared to lean, non-T2D mice (Supplementary Fig. 1a), and increased ~3.2-fold in T2D KKAy mice compared to non-T2D control KKAa mice (Supplementary Fig. 1b).