Similarly, SWELL1 protein is 50% lower in adipose tissue from individuals with hyperglycemic T2D and obesity (HgbA1c > 6.0%) compared to adipose tissue from normoglycemic individuals (HgbA1c < 6.0% Fig. 1k and Supplementary Table S4). This evidence concerns the gene LRRC8A and type 2 diabetes mellitus.