LRRC8A and type 2 diabetes mellitus: In both mouse and human T2D β-cells, the maximum ICl,SWELL current density (measured at +100 mV) upon stimulation with hypotonic swelling is significantly reduced (90% in murine; 63% in human, Fig. 1c, d) compared to non-T2D controls, similar to reductions observed in SWELL1 knockout (KO) and knockdown (KD) murine and human β-cells28, respectively.