ITGA4 and central nervous system cancer: We found increased levels of ITGA4 in poor-surviving groups as compared to cluster groups with better survival across all 3 datasets for IDH-WT tumors and in 2/3 datasets for IDH-MUT tumors (Additional file 7: Figure S7A), suggesting a link between macrophage abundance, immune-based clusters, and the patient outcome in both IDH-WT and IDH mut gliomas.