In humans, TACI (TNFRSF13B) gene mutations in humans are shown in about 10% of patients with Common Variable Immuno-Deficiency (CVID) disorder, which manifests with impaired antibody production and are more susceptible to Streptococcus pneumoniae and Hemophilus influenzae infections, as well as autoimmune diseases [54, 55]. This evidence concerns the gene TNFRSF13B and autoimmune disease.