In addition, P53 and Rb were also showed significant distinction: Diffusely strong positivity of P53 could be seen in most LCNEC-nulls (9 / 11, 81.8%) and LCNECs (8 / 13, 61.5%) while all LCCs were negative (p = 0.003). This evidence concerns the gene RB1 and large cell neuroendocrine carcinoma.