Analysis of cortical neurons from 6 control cases and 12 MS cases (6 progressive MS, 1 RRMS and 5 unknown disease courses) demonstrated significant mislocalization of the RBPs hnRNP A1 and TDP-43, demonstrating that dysfunctional RBPs may contribute to neurodegeneration in progressive MS as in other neurological diseases [255]. This evidence concerns the gene TARDBP and myeloid sarcoma.