Using biochemical and genotype data, PCOS can be classified into a “reproductive” subtype which presents higher luteinizing hormone (LH) and sex hormone-binding globulin (SHBG) levels with relatively low BMI, and a “metabolic” subtype which presents higher BMI, glucose, and insulin levels with lower SHBG and LH levels [69]. The gene discussed is SHBG; the disease is polycystic ovary syndrome.