In summary, MUC1-rs4072037 is significantly genome-wide associated with CA153 level (p = 1.28E-18) and 30 genetic loci were suggestively genome-wide associated with level of tumor markers (AFP, CA50, CA125, CA153, CA19-9, CEA, f-PSA, SCC-Ag) among the Han population from Southern China. This evidence concerns the gene KLK3 and neoplasm.