Release of proinflammatory cytokines into the circulation (cytokine storm) and disseminated intravascular coagulation are markers of severe COVID-19 (1, 2, 3), and integrin α5β1 activation leads to NF-κB-dependent upregulation of proinflammatory cytokines, chemokines, and coagulation factors in ECs (18). This evidence concerns the gene NFKB1 and COVID-19.