Importantly, in the presence of anti-rheumatic drugs that target immunometabolic pathways (such as MTX), IL-17 signaling amplifies neutrophil chemotactic protein (IL-8, CXCL1 and CXCL2) expression in fibroblast-like synoviocytes, pointing towards a key role for musculoskeletal stroma in regulating inflammatory chemokine expression during joint inflammation. The gene discussed is IL17A; the disease is Arthritis.