In the current study, we used p53-wildtype neuroblastomas, SK-N-SH, SH-SY5Y, SK-N-AS, and Lan-5, to test the hypothesis that cells with wildtype p53 that are sensitive to the combination of SN38 and UCN-01 will fail to form tetramers upon DNA damage. The gene discussed is TP53; the disease is neuroblastoma.