Using a Cox Proportional Hazards regression model analysis, we found 7 independent predictors of MACE occurrence during follow up, including CAD duration (HR = 0.77; 95% CI = 0.72–0.84; p < 0.001), COPD/Asthma (HR 1.28; 95% CI = 1.04–1.59; p = 0.021), heart valve disease (HR = 1.22; CI 95% = 1.02–1.46; p = 0.031), MVD (HR = 1.27; 95% CI = 1.07–1.51; p = 0.005), insulin treatment (HR = 1.53; CI 95% = 1.26–1.85; p < 0.001), statins treatment (HR = 0.62; CI 95% = 0.48–0.81; p < 0.001), and clopidogrel treatment (HR = 0.83; CI 95% = 0.70–0.99; p = 0.039) (Table 3). The gene discussed is INS; the disease is chronic obstructive pulmonary disease.