To do so, we modified a previously-employed BMDM phagocytosis assay (as BMDMs are both models for activated microglia and are known to migrate into the brain in late-stage AD), to use fluorescently labeled Aβ42 to determine if the phagocytosis of Aβ42 is controlled by the circadian clock [28,36–38]. This evidence concerns the gene CLOCK and Alzheimer disease.