RNA immunoprecipitation (RIP) and sequencing experiments in UV-crosslinked memory T lymphocytes using an anti-PDAP1 antibody revealed several factors crucial in the regulation of T-cell biology that were bound by PDAP1, most prominently some regulators of T-cell activation, differentiation, and proliferation such as CBL [34], NOTCH factors [35], and the multiple sclerosis susceptibility gene PRKCA [36,37] (Fig 4C, S5A Fig, S5 Table). This evidence concerns the gene PDAP1 and multiple sclerosis.