ERBB2 and breast cancer: In multivariable regression analyses, we found that the risk factors significantly associated with BRCA PVs carrier status in this study were consistent with previously published findings from Asian countries, including younger age of diagnosis, bilateral breast cancer, ER-negative status, HER2-negative status, higher grade, and presence of first degree family history of breast cancer or ovarian cancer.20,22,30,31,32,33,34,35,36,37,38