Indeed, higher grade was identified as a strong predictor not only for BRCA1 PVs carriers but also for BRCA2 PVs carriers.42 Previous studies have shown that inclusion of grade can improve the sensitivity and discrimination of germline BRCA PVs prediction in high-risk breast cancer patients.44,45 Given that BRCA1 (91%) and BRCA2 (89%) PVs carriers were of higher grade than in non-carriers (76%), future improvements in BRCA carrier prediction tools could include grade.45,49. Here, BRCA1 is linked to breast cancer.