More specifically, they show strong antinociceptive andanti-inflammatory activities.14 Similarly,recent reports have described them as the only nonpeptidic agonistsof GLP-1R (glucagon-like peptide 1 receptor), which is widely usedin the treatment of diabetes.15 Despitetheir importance and properties, the availability of synthetic methodsfor accessing 1,3-diaminotruxillic and 1,2-diaminotruxinic derivativesis somewhat limited. The gene discussed is GLP1R; the disease is diabetes mellitus.