TOP2A and tuberculosis: Of the vital cellular processes targeted by TB drugs in clinicaluse, DNA replication stands out as relatively under-represented;6−8 this is despite the high vulnerability of some genes essential forDNA replication in Mtb,9 including those encoding DNA gyrase, the target of the fluoroquinolones,moxifloxacin, gatifloxacin, and levofloxacin, and the only DNA metabolicenzyme currently targeted for TB therapy.