Interestingly, Paul et al [12] identified one DMC (hg19: chr10:74058002) in purified CD4+ T cells between individuals with type 1 diabetes and their healthy co-twins in the intergenic region between DDIT4 and DNAJB12. In our study, we found a DMR (chr10:74082048-–74,082,090) region hypermethylated in cases in CD4+ T cells in pre-seroconverted samples located in the same intergenic region (Fig. 6c). Here, CD4 is linked to type 1 diabetes mellitus.