To overcome the shortcomings of using only anti-AChR antibody tests, which can miss a substantial proportion of cases, some have argued that testing for acetylcholine receptor, acetylcholinesterase, titin and ryanodine receptor antibodies together can offer a better diagnostic method for MG than each antibody test alone [29] but this is not accepted as a standard in routine clinical practice. This evidence concerns the gene ACHE and myasthenia gravis.