PSEN1 and Alzheimer disease: Notably, mutations in presenilin 1 that cause familial forms of AD disrupt lysosome function and autophagy (Cataldo et al., 2004; Coen et al., 2012; Lee et al., 2015; Lee et al., 2010; Neely et al., 2011; Tong et al., 2021), linking lysosomal impairments directly to AD.