SOD1 and amyotrophic lateral sclerosis: Similarly, in a familial ALS-linked mouse model with the G93A mutation in human SOD1, mutant SOD1 (hSOD1G93A) interacts with DIC (Zhang et al., 2007) and interferes with dynein loading onto LEs, resulting in impaired retrograde transport and autophagy-lysosomal deficits in ventral root axons (Fig. 4 B; Xie et al., 2015).