Interestingly, it was also observed that the elevation of miR-29 c-3p improved the production of serum sex hormones and glucose metabolism in PCOS rats, for the grounds of giving rise to a declination in the production of FSH, LH, E2, PRL, T, HOMA-IR, BG120min, INS120min, GnRH, IAA, ICA and GAD, but an augmentation in the production of P. But augmented Foxo3 was able to reverse the impacts of elevation of miR-29 c-3p on serum sex hormone production and glucose metabolism in PCOS rats. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.