Protein and mRNA levels of TRIM37, TRIM52, TRIM55, and TRIM59 were increased in HCC tissues compared with normal liver samples by immunohistochemical experiments (p = 4.6E‐28, p = 0.07, p = 1.2E‐04 and p = 1.3E‐17, respectively) (Figure 3G,I–K,R,T–V). The gene discussed is TRIM59; the disease is hepatocellular carcinoma.