Based on Oncomine, the mRNA expression levels of TRIM6, TRIM11, TRIM16, TRIM24, TRIM28, TRIM31, TRIM37, TRIM45, TRIM52, and TRIM59 in HCC tissues were significantly elevated in HCC versus normal liver tissue, and TRIM55 was remarkably downregulated in normal liver tissues. Here, TRIM28 is linked to hepatocellular carcinoma.