The results of Wurmbach,19 Mas,21 Chen,20 and Roessler22 all suggest that TRIM52 is significantly upregulated in HCC with a fold change of 2.319 (p = 1.76E‐6), 1.148 (p = 0.004), 1.303 (p = 2.42E‐5), and 1.338 (p = 4.17E‐18), respectively. This evidence concerns the gene TRIM52 and hepatocellular carcinoma.