Based on Oncomine, the mRNA expression levels of TRIM6, TRIM11, TRIM16, TRIM24, TRIM28, TRIM31, TRIM37, TRIM45, TRIM52, and TRIM59 in HCC tissues were significantly elevated in HCC versus normal liver tissue, and TRIM55 was remarkably downregulated in normal liver tissues. The gene discussed is TRIM59; the disease is hepatocellular carcinoma.