Briefly, the Kaplan–Meier survival curve and log‐rank test analyses suggested that the increased TRIM24, TRIM28, TRIM37, TRIM45, and TRIM59 mRNA levels were significantly correlated with poor OS (p = 0.026, 0.00055, 0.00043, 0.0029, and 0.0054, respectively), PFS (p = 0.0068, 0.0071, 2.8E‐5, 8.6E‐5, and 0.0018, respectively), DSS (p = 0.0042, 0.0057, 0.00031, 0.0038, and 0.0032, respectively), and RFS (p = 0.0058, 0.003, 8.3E‐5, 0.00018, and 0.026, respectively) of all the patients with HCC. This evidence concerns the gene TRIM59 and hepatocellular carcinoma.