There were significant differences in SLEDAI, total glyceride (TG), serum amyloid A (SAA), SAR, urinary microalbumin‐to‐creatinine ratio (ACR), erythrocyte sedimentation rate (ESR), albumin (ALB), complement 3 (C3), anti‐dsDNA, anti‐Sm positive rate, and anti‐dsDNA positive rate between active SLE and stable SLE patients. The gene discussed is C3; the disease is systemic lupus erythematosus.