In the multivariate analysis, we found that TG, SAR, ACR, and positive anti‐dsDNA were independent influencing factors of active SLE, while C3 was protective factor of active SLE, and the OR values were 2.342, 10.921, 1.451, 2.476, and 0.832, respectively (p < 0.05), but positive anti‐Sm was not an independent factor of active SLE (p > 0.05). This evidence concerns the gene C3 and systemic lupus erythematosus.