MAPT and synucleinopathy: Our in vitro data here and a recently published in vivo model [46] indicate a causal role for αSH destabilization in neurodegeneration, but it remains unclear whether further shifts in the equilibrium of αSH and αSU are a part of ongoing progressive pathology in synucleinopathies, maybe further accelerated by the presence of tau or Abeta pathology in the case of DLB.