It was shown that COX-2 inhibitor causes DNA double-strand breaks and forms reactive oxygen species, followed by downregulation of expression of phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and mitogen-activated protein kinase, finally inducing apoptosis of cancer cells in BNCT (Figure 4).93 Here, PTGS2 is linked to cancer.