EGFR and cancer: ,198 EGFR-mediated cellular events are interfered with by inhibiting EGF from binding to EGFR on the surface of cancer cells.199, 200, 201 By employing the carborane cage as a pharmacophore, Viñas’ group demonstrated that a carborane-containing erlotinib derivative, 1,7-closo-carboranylanilinoquinazoline (36, Figure 6D), had a higher affinity than its parent compound erlotinib.201