Cyclooxygenase-2 (COX-2) is highly expressed in HNC,93, 94, 95 which can be used as a potential target for HNC.96, 97, 98, 99 The Chen group developed a novel carborane-containing COX-2 inhibitor (9), which was able to induce apoptosis of cancer cells through BNCT and was effectively used for the treatment of HNC.93 The gene discussed is PTGS2; the disease is cancer.