Hepatocellular carcinoma (HCC) is the most common cause of death from cancer.70, 71, 72, 73, 74, 75 D’Souza and Devarajan reported that the asialoglycoprotein receptor (ASGPR) could serve as an ideal target specific for delivery to HCC.76 The gene discussed is ASGR1; the disease is hepatocellular carcinoma.