Denny et al. reported that lupus LDGs express a higher level of IFN-α mRNA and secrete increased TNF-α and IFN-γ upon phorbol-12-myristate-13-acetate (PMA) stimulation when compared to autologous lupus NDNs and NDNs from HCs [14]. The gene discussed is TNF; the disease is systemic lupus erythematosus.