An in vitro cell experiment showed increased secretion of galectin-3 after stretching cardiac muscle cells (18), Galectin-3 can increase infiltration of macrophages and mast cells in myocardial cells, leading to myocardial fibrosis, myocardial stiffness and left ventricular dysfunction (15, 19). The gene discussed is LGALS3; the disease is Myocardial fibrosis.