In patients with cirrhosis, hepatocytes were induced to secrete Galectin-3, while normal hepatocytes had a decreased scavenging effect on galectin-3, which ultimately leaded to an increase in serum galectin-3 concentration, while the latter promoted the deterioration of liver cirrhosis by inducing activation of hepatic stellate cells and fiber synthesis (48). Here, LGALS3 is linked to cirrhosis of liver.