Patients with AF progression were older (70.9 ± 8.0 vs. 62.3 ± 10.3 p < 0.001), had significantly increased levels of NT-proBNP (484.5 vs. 183.6 p = 0.004), HATCH score (2 vs. 1 p = 0.002), and LAD (40.7 ± 4.8 vs. 38.7 ± 4.7 p = 0.028), and decreased level of e-GFR (80.5 ± 16.8 vs. 91.5 ± 15.1 p < 0.001) and LTL (1.2 ± 0.3 vs. 1.5 ± 0.3 p < 0.001), and higher proportion of HF (38.2% vs. 20.2% p = 0.039) and COPD history (8.6% vs 1.7% p = 0.043) than those who did not progress. This evidence concerns the gene NPPB and chronic obstructive pulmonary disease.