The high expression of BUB1 (HR = 1.6), PRC1 (HR = 1.7), CCT5 (HR = 1.5), and DDX39B (HR = 1.4) were remarkably correlated with poorer DFS of HCC patients (log-rank p < 0.05). The gene discussed is BUB1; the disease is hepatocellular carcinoma.