In peripheral blood of NSCLC patients, CD8+ T cells and CD8+ PD-1 maintained a high level in 6.2 Gy × 4 F, and CD8+ T cells also increased in 10 Gy × 2 F. Besides, DC cells began to be significantly increased after radiotherapy in all fractionations in mice. Here, PDCD1 is linked to non-small cell lung carcinoma.