Biomarkers related to endothelial damage, including serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), endothelin-1 (ET-1), and von Willebrand factor (vWF), were found to be expressed at high levels in patients with MDA5+ DM. This evidence concerns the gene VWF and dermatomyositis.