Among the 242 eyes, 17 eyes were diagnosed with AP-ROP, while the other 225 type 1 ROPs with plus disease were also included (6 eyes with Zone I, Stage 2; 15 eyes with Zone I, Stage 3; 69 eyes with Zone II Stage 2; and 135 eyes with Zone II, Stage 3); all of them were initially treated with anti-VEGF agents. Here, VEGFA is linked to retinopathy of prematurity.