HIF1A and cancer: In previous study, researcher identified hypoxia can induced the sumolytion of m6A enzyme(Hou et al., 2021), hypoxia-inducible factor-1 alpha (HIF-1α) can drive m5C modification to promote tumorigenesis(Wang J. Z. et al., 2021), m1A and m6A modification can significantly affect the infiltration of immune cells(Cai et al., 2021; Gao et al., 2021), m7G modification can drives immune evasion (Devarkar et al., 2016), and m6A, m7G modification can induce EMT in cancer development (Yu X. et al., 2020; Xia et al., 2021).