Besides, colony formation assay and flow cytometry demonstrated that silencing IGF2BP2 potentiated the effect of etoposide to promote apoptosis and inhibit survival of glioma cells, whereas overexpression of DANCR exerted the opposite effect, abrogating the effect of sh-IGF2BP2 on glioma cells (Figures 3F,G; Supplementary Figure S1A). Here, IGF2BP2 is linked to central nervous system cancer.