SERPINE1 and cancer: Moreover, a pan-cancer analysis revealed that high expression of the fibrinolysis gene clusters PLAU, PLAUR, and SERPINE1 was consistently correlated with a high expression of tumor microenvironment (TME) monocyte infiltration features and important checkpoints of the immune response, such as PD-L2 and CD276/B7-H3 (Saidak et al., 2021).