Prolonged mechanical ventilation and repeated intubation/extubation are important risk factors for BPD, and we also found serum NT-proBNP level could precisely predicted weaning failure of infants with RDS (ROC-AUC: 0.977; 95% CI: 0.918–0.997; p < 0.001) (18). The gene discussed is NPPB; the disease is bronchopulmonary dysplasia.