Importantly, for both these groups of treated mice, we observed reduced numbers of bacteria in the nasal cavity and middle ears, indicating that the transferred splenocytes controlled the unrestricted growth of bacteria otherwise observed in Rag-1−/− mice and reduced their numbers by ~99% to the levels seen for the wild-type C57BL/6J mice at the corresponding day 28 time point of infection (refer to Figure 1). The gene discussed is RAG1; the disease is infection.