BRAF and melanoma: We chose 6 mg/kg of DMF and 25 mg/kg of Vem (40) in our study, which correspond to the human dose given orally to psoriatic patients at 240 mg twice daily (28) and the human dose given orally to patients with BRAF-mutant melanoma at 960 mg twice daily (41) (as measured per kilogram body weight), respectively.