Here our results that 50 μM of DMF induced GSH depletion (Supplementary Figure 2) and increased expression and nuclear translocation of NRF2 as well as the protein levels of HO-1 and NQO1 in melanoma cells (Figures 3A–G) were consistent with the previous observations (32), suggesting DMF have similar functions in melanoma as in other cancer lines. The gene discussed is NFE2L2; the disease is cancer.